Parvalbumin-producing cortical interneurons receive inhibitory inputs on proximal portions and cortical excitatory inputs on distal dendrites
نویسندگان
چکیده
منابع مشابه
Simulating inputs of parvalbumin inhibitory interneurons onto excitatory pyramidal cells in piriform cortex
The balance of excitation and inhibition within most sensory cortices is co-tuned to a given stimulus. However, unlike other sensory cortices, it has been reported from in vivo recordings that widespread global inhibition governs sparse stimulus-evoked excitation in the piriform cortex. Further in vitro physiology has demonstrated that this global inhibition is achieved through local activation...
متن کاملBalanced excitatory and inhibitory inputs to cortical neurons decouple firing irregularity from rate modulations.
In vivo cortical neurons are known to exhibit highly irregular spike patterns. Because the intervals between successive spikes fluctuate greatly, irregular neuronal firing makes it difficult to estimate instantaneous firing rates accurately. If, however, the irregularity of spike timing is decoupled from rate modulations, the estimate of firing rate can be improved. Here, we introduce a novel c...
متن کاملEffects of common excitatory and inhibitory inputs on motoneuron synchronization.
We compared the effects of common excitatory and inhibitory inputs on motoneuron synchronization by simulating synaptic inputs with injected current transients. We elicited repetitive discharge in hypoglossal motoneurons recorded in slices of rat brain stem using a combination of a suprathreshold injected current step with superimposed noise to mimic the synaptic drive likely to occur during ph...
متن کاملDevelopmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex.
Working memory requires efficient excitatory drive to parvalbumin-positive (PV) interneurons in the primate dorsolateral prefrontal cortex (DLPFC). Developmental pruning eliminates superfluous excitatory inputs, suggesting that working memory maturation during adolescence requires pruning of excitatory inputs to PV interneurons. Therefore, we tested the hypothesis that excitatory synapses on PV...
متن کاملSummation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites.
We investigated summation of steady excitatory and inhibitory inputs in spinal motoneurons using an in vivo preparation, the decerebrate cat, in which neuromodulatory input from the brain stem facilitated a strong persistent inward current (PIC) in dendritic regions. This dendritic PIC amplified both excitatory and inhibitory synaptic currents two- to threefold, but within different voltage ran...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2012
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2012.08027.x